1). Open in a separate window Figure 1 Epithelial-mesenchymal transition is induced by the MEK/ERK signaling pathway in mouse ovarian carcinoma cells. pathway-targeted therapy, PD98059, PI3K/Akt/mTOR, rapamycin, tumor resistance Progress in the development of effective therapies is hindered by a lack of understanding about the complexities of biochemical pathways that are required for tumor maintenance …