PIP2

Courtney Houchen has ownership interest with COARE Biotechnology

Courtney Houchen has ownership interest with COARE Biotechnology. improved phosphorylation of GSK-3 at Ser9. This was associated with an induction of a 48-kDa active -catenin having a maintained hypophosphorylated N-terminus that interacted with nuclear TCF-4 resulting in luciferase reporter activity and cyclin D1 manifestation. DCLK1 downregulation inhibited 48-kDa -catenin manifestation. The proteasome inhibitor bortezomib did …

Our previous studies have demonstrated that rapid nucleoplasmic accumulation of SENP3 is because of the oxidation of one of two cysteines in the redox-sensing domain name, which leads to the blockage of ubiquitination and proteasomal degradation (33)

Our previous studies have demonstrated that rapid nucleoplasmic accumulation of SENP3 is because of the oxidation of one of two cysteines in the redox-sensing domain name, which leads to the blockage of ubiquitination and proteasomal degradation (33). we found that SENP3 deficiency markedly compromises the activation of TLR4 inflammatory signaling and the production of proinflammatory …