PIP2

Our previous studies have demonstrated that rapid nucleoplasmic accumulation of SENP3 is because of the oxidation of one of two cysteines in the redox-sensing domain name, which leads to the blockage of ubiquitination and proteasomal degradation (33)

Our previous studies have demonstrated that rapid nucleoplasmic accumulation of SENP3 is because of the oxidation of one of two cysteines in the redox-sensing domain name, which leads to the blockage of ubiquitination and proteasomal degradation (33). we found that SENP3 deficiency markedly compromises the activation of TLR4 inflammatory signaling and the production of proinflammatory …