HRMSCFAB: calcd for C18H18N2O [M]+: 278.1419; discovered: 278.1422.= 3.6 Hz, 2 H, CH2), 3.75 (s, 3 H, Me), 4.94 (d, = 17.2 Hz, 1 H, C=CH), 5.03 (d, = 10.5 Hz, 1 H, C=CH), 5.89 (m, 1 H, C=CH), 6.77 (d, = 8.8 Hz, 2 H, ArH), 7.14 (m, 4 H, ArH), 7.33 (m, 3 H, ArH). 151.92. HRMSCFAB: calcd for [MH]+ C14H15N4O4: 303.1093; discovered: 303.1071.= 5.7 Hz, 2 H, CH2), 4.75 (dd, = 1.7, 17.1 Hz, 1 H, CH), 4.92 (dd, = 1.5, 10.1 Hz, 1 H, CH), 5.69 (m, 1 H), 7.25 (d, = 8.4 Hz, 2 H, ArH), 7.77 (d, = 8.8 Hz, 2 H, ArH). 13C NMR (125 Rabbit polyclonal to GNMT MHz, CDCl3): = 11.23, 12.29, 22.6, 27.18, 115.30, 118.79, 127.41, 129.77, 134.74, 135.44, 140.33, 144.91, 153.49. HRMSCFAB: calcd for [MH]+ C15H19N2O2S: 291.1167; discovered: 291.1178.= 5.8 Hz, 2 H, CH2), 4.98 (d, = 17.1 Hz, 1 H, CH), 5.0 (d, = 10.1 Hz, 1 H, Miriplatin hydrate CH), 5.85 (m, 1 H), 7.54 (d, = 8.4 Hz, 2 H, ArH), 8.15 (d, = 8.5 Hz, 2 H, ArH), 9.98 (br s, 1 H, OH). 13C MR (125 MHz, CDCl3): = 11.21, 11.73, 27.76, 114.93, 116.53, 123.71, 127.77, 131.13, 135.85, 136.89, 143.92, 149.37, 170.42. HRMSCFAB: calcd for [MH]+: C15H17N2O2: 257.1290; discovered: 257.1287.= 7.5 Hz, 3 H, Me), 1.18 (t, = 7.5 Hz, 3 H, Me), 2.49C2.52 (two quart are overlapping, 2 2 H, 2 CH2), 3.08 (dd, = 1.6, 4.7 Hz, 2 H, CH2), 3.71 (s, 3 H, Me personally), 4.91 (d, = 7.3 Hz, 1 H, CH), 4.93 (d, = 7.8 Hz, 1 H, CH), 5.86 (m, 1 H). 13C NMR (125 MHZ, CDCl3): = 13.55, 13.89, 17.4, 19.81, 27.67, 35.73, 113.1, 114.26, 137.53, 141.92, 151.26. HRMSCFAB: calcd for C11H19N2 [MH]+: 179.1548; discovered: 179.1572.= 1.9, 3.3 Hz, 2 H, CH2), 5.02 (dd, = 1.8, 17.0 Hz, 1 H, CH), 5.11 (dd, = 1.8, 10.3 Hz, 1 H, CH), Miriplatin hydrate 6.00 (m, 1 H), 7.24C7.25 (m, 1 H, ArH), 7.27C7.30 (m, 4 H, ArH), 7.31C7.33 (m, 6 H, ArH), 7.34 (t, 2 H, = 6.5 Hz, ArH), 7.42 (d, 2 H, = 6.7 Hz, ArH). 13C NMR (125 MHz, CDCl3): = 28.16, 115.85, 115.93, 124.7, 126.76, 127.7, 127.93, 128.32, 128.37, 128.42, 128.66, 129.91, 130.61, 133.65, 137.61, 140.13, Miriplatin hydrate 142.0, 151.48. HRMSCFAB: calcd for C24H21N2 [MH]+: 337.1705; discovered: 303.1721.= 18.4 Hz, CH), 5.08 (d, 1 H, = 9.3 Hz, CH), 5.98 (m, 1 H), 6.79 (br d, 2 H, = 6.1 Hz, ArH), 7.22C7.25 (m, 4 H, ArH), 7.29C7.32 (m, 4 H, ArH), 7.42 (br d, 2 H, ArH), 7.81 (d, 2 H, = 6.7 Hz, ArH). 13C NMR (125 MHz, CDCl3): = 28.22, 55.39, 113.86, 115.44, 115.75, 126.15, 127.59, 127.93, 128.20, 128.34, 128.36, 128.57, 128.86, 129.96, 130.67, 133.52, 133.79, 137.67, 141.98, 151.06, 158.36. HRMSCFAB: calcd Miriplatin hydrate for C25H23N2O [MH]+: 367.1810; discovered: 367.1826.= 6.9 Hz, 1 H, ArH), 7.38C7.45 (m, 7 H, ArH), 7.71 (br d, = 7.2 Hz, 2 H, ArH). 13C NMR (125 MHz, CDCl3): = 23.06, 32.19, 37.26, 111.47, 114.1, 127.23, 127.44, 127.94, 128.26, 128.47, 128.5, 129.48, 130.35, 133.97, 143.01, 145.3, 149.71. HRMSCFAB: calcd for C20H21N2 [MH]+: 289.1705; discovered: 289.1722.= 7.2 Hz, 2 H, ArH), 7.25 (m, 4 H, ArH), 7.32 (br t, = 7.1 Hz, 4 H, ArH), 7.42 (d, = 7.4 Hz, 2 H, ArH), 7.81 (d, = 7.1 Hz, 2 H, ArH). 13C NMR (125 MHz, CDCl3): = 23.28, 32.33, 55.39, 111.87, 113.84, 115.78, 126.14, 127.52, 127.70, 128.14, 128.57, 129.68, 129.88, 133.51, 133.74, 142.03, 145.47, 151.19, 158.3. HRMSCFAB: calcd for C26H24N2O [M]+: 380.1889; discovered: 380.1891.= 5.6, 1.7 Hz, 2 H, CH2), 3.75 (s, 3 H, Me), 4.98 (ddt, = 20.0, 1.8, 1.8 Hz, 1 H, CH), 5.03 (ddt, = 10.3, 1.7, 1.7 Hz, 1 H, CH), 5.90 (ddt, = 17.0, 10.0, 5.6 Hz, 1 H, CH), 6.75 (m, = 9.1 Hz, 2 H, ArH), 7.09 (m, = 9.1 Hz, 2 H, ArH), 7.13C7.15 (m, 2 H, ArH), 7.27C7.30 (m, 3 H, ArH). 13C.